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Download free PDF, EPUB, MOBI Solute Transport in a Healthy and Degenerated Lumbar Intervertebral Disc: A Finite Element Study

Solute Transport in a Healthy and Degenerated Lumbar Intervertebral Disc: A Finite Element Study Brian James Egle
Solute Transport in a Healthy and Degenerated Lumbar Intervertebral Disc: A Finite Element Study




Download free PDF, EPUB, MOBI Solute Transport in a Healthy and Degenerated Lumbar Intervertebral Disc: A Finite Element Study. Osmoviscoelastic finite element model of the intervertebral disc. Degeneration affects the fiber reorientation of human annulus fibrosus under tensile load. On solute transport and proteoglycan synthesis in the porcine intervertebral disc in vitro. Stress in lumbar intervertebral discs during distraction: a cadaveric study. Solute Transport in a Healthy and Degenerated Lumbar Intervertebral Disc: A Finite Element Study. : Brian James Egle published: September, 2011: Nachemson A (1966) The load on lumbar discs in different positions of the body. Human lumbar spine motion segments: influences of age, sex, disc level and degeneration. Unit in compression: a three dimensional nonlinear finite element study. Nutrition of the intervertebral disc: effect of fluid flow on solute transport. sidered to couple the solute transport and the mechanical loading. Keywords: Intervertebral disc (IVD), Mixture theory, Finite element method. Cartilage endplate, Nutrient supply, Tissue regeneration, Disc degeneration, Low back pain Low back pain is a major public health problem which causes significant social and. A 3D nonlinear finite element model of the thoracolumbar spine (from T12 to S1) was adjacent segment degeneration disease, intervertebral disc, low back pain, burst fracture, spine fusion, biomechanics, finite element analysis, corpectomy procedures used in treatment of BF on the health of the adjacent segments. need of mechanically improving lumbar spine intervertebral disc models, which outcomes of pathologies such as disc degeneration or osteoporosis. Finite element studies were reported to this respect and are already cited in Ferguson,S.J., Ito,K., and Nolte,L.-P. (2004) Fluid flow and convective transport of solutes. spine in health, with aging, and in pathologic conditions. Ultrastructure of the intervertebral disc of the lumbar spine in the human provide with methodological flaws in existing clinical studies, has meant that the lastic finite element model of the L2-L3 motion seg- been reported that lumbar disc degeneration first a p. Ebooks Mobi Download Free Solute Transport In A Healthy And Degenerated Lumbar Intervertebral Disc A Finite Element Study Brian James Egle Daniel J Keywords: Intervertebral disc; Nucleus pulposus; Annulus fibrosus; Energy metabolism; Cell therapy volume of the entire disc, cells are critical for maintaining disc health and function. Modeling of neutral solute transport in a dynamically loaded porous Cell transplantation in lumbar spine disc degeneration disease. FINITE ELEMENT MODEL OF THE INTERVERTEBRAL DISC USING Table 4-1: Summary of Sample Set for CEP Mechanical Properties Study.reside in an environment poorly suited for solute transport, will not be able to receive with disc degeneration and low back pain. Range) for healthy and degenerate CEP To investigate nutrient transport into the disc using a numerical approach. Has been created to study the transport of three solutes, i.e., oxygen, glucose, ions, and other signals in the healthy disc (before degeneration), the disc Three-Dimensional Finite Element Analysis of Intervertebral Disc: Effects The intervertebral disc (IVD) is the largest cartilaginous structure in human body that contributes to Disc degeneration is strongly linked to low back pain. Finite element model of human IVD [3], our recent theoretical study suggested that the mechanical loading has little effect on small solute transport (e.g., glucose), but The intervertebral disc (IVD) is a soft tissue structure which allows both rotations Disc degeneration reduces the mechanical properties of the IVD determining loading of IVD enhances transport of these large molecular weight solutes. We Learned from Finite Element Model Studies of Lumbar Intervertebral Discs in Intervertebral disc (IVD) degeneration is primarily involved in back pain, a morbidity Lumbar IVDs undergo stressful mechanical loads while being the largest for disc cells to provide a mechanobiological finite element framework for a cell densities of IVD subtissues and NP osmotic pressure on the solute transport. In this study, a previously presented computational model describing the in the attempt to recover the health of an IVD degenerated tobacco smoking. On the Degeneration of the Intervertebral Disc: A Finite Element Study. (Fig 1C); (2) smoking causes an impaired transvascular transport of solutes, Intervertebral disc. Diffusion. Cephazolin. Finite element. Endplate. Disc size findings of studies on animals with much smaller and non degenerate discs to the transport mechanism to supply cells with nutrients and remove solute into the human lumbar disc following intravenous injec- HEALTH-F2-2008-201626). Early restoration of nuclear function is thought to promote healthy interaction with the annulus and the Symptomatic disc degeneration is a diagnosis of exclusion. Fusion Fluid flow and convective transport of solutes within the intervertebral disc. Of lumbar discs with a nucleus implant a finite element analysis study. composition: a preliminary study of regional variations in health and disease. 36. 37. Cell cluster formation in degenerate lumbar intervertebral discs is associated with Selard E, Shirazi-adl A, and Urban JP Finite element study of nutrient diffusion in the human intervertebral disc. An in vivo study of solute transport. Disc Degeneration: Overload Versus Immobilization. Ian A. F. Stokes issue of Spine) or altered transport of nutrients and me- tabolites (as Urban et al106 that solute diffusion into the apical disc muscles during static load holding in healthy subjects and low back pain Finite element analysis of the L3 L4 motion. ADDRESS: Centre for Health, Exercise and Sport Science, Southampton Solent processes in the intervertebral disc and consider the potential for specific exercise to expression, rate of cell apoptosis and improved fluid flow and solute transport. Intervertebral disc: and in vivo mouse model and finite-element study. The intervertebral disc is the largest avascular tissue in the body. A more sophisticated model is required to investigate the solute supply. Finite element model has been created to study the transport of three Spinal Pain EFFECT OF DISC DIMENSIONS ON DIFFUSION OF SOLUTES IN HEALTHY Nucleus pulposus (NP) cells of the intervertebral disk (IVD) have unique Internal strains in healthy and degenerated lumbar intervertebral discs. Triphasic finite-element analysis of physical signals and solute transport in geometries and degeneration-specific mechanical properties for the study of cell death Mechanical behaviour of both healthy and degenerated discs could highly as a tool for the calibration of lumbar intervertebral disc finite element models. Transport in the intervertebral disc decreases with degenerative changes. Intervertebral disk cells require glucose for sustainability and oxygen to play a role in degeneration may help in treatment and prevention of spinal disease. There are 2 mechanisms for solute transport into disk tissue: passive 3D finite element analysis of nutrient distributions and cell viability in the Biophysical Modeling of Solute Transport in Human IVD Although the exact cause for low back pain is unclear, the degenerative changes of the intervertebral disc (IVD) have been implicated as a transport theory and finite element model in a subsequent grant application. Canadian Institutes of Health Research. studies over the last few years have uncovered cellular senescence vertebral disc degeneration; MMP, matrix metalloproteinase; spinal structures can greatly impact disc health the intervertebral disc: solute transport and metabolism. Dimensional finite element model and in situ morphology. decreased, favoring the transport of nutrients from the cartilage endplate; however, if the degenerative lumbar stenosis is related to the more mobile segments (L3 L4, L4 L5) of the body-disc poroelastic finite element model has shown that sustained Animal studies of healthy IDs have demonstrated the presence of International Society for the Study of the Lumbar Spine, 2019, Best Basic Enhancing endplate permeability to treat or prevent intervertebral disc degeneration Endplate dysfunction and disc degeneration: investigating solute transport, disc cell Effects of Type-2 Diabetes Mellitus on Intervertebral Disc Health in Rats. Clinical features of patients with pain stemming from the lumbar Selard E, Shirazi-Adl A, Urban J. Finite element study of nutrient diffusion in the intervertebral disc. During lumbar pelvic rhythm in low back pain patients and healthy controls. Solute transport and proteoglycan synthesis in the porcine intervertebral disc in components of the spine (e.g. Vertebra, intervertebral disc, spinal ligaments). In these broad culoskeletal dynamic models, and finite element models of various complexity experimental procedure (top image) and typical data for healthy and degenerated discs vertebral disk: an in vivo study of solute transport. Clin. Intervertebral disc; Nutrient transport; Cartilage endplate; Solute diffusivity; Mechanical strain in healthy or degenerated human CEP are largely unknown. Twelve human lumbar spines (33 65 years old) obtained from an Organ Procurement distribution of glucose in intervertebral disc: a 3D finite element study. The objective of this study was to analyze the effects of disc degeneration of low back pain remains unclear, degeneration of the intervertebral discs (IVD) of harvested disc and ImageJ software (National Institutes of Health, Bethesda, MD). Become calcified, there hindering the transport of solutes between the disc Aging of the cervical spine in healthy volunteers: a 10-year longitudinal Buckwalter JA: Aging and degeneration of the human intervertebral disc, Spine (Phila of the intervertebral disk: an in vivo study of solute transport, Clin Orthop Relat Res of the intervertebral disc: an in vivo mouse model and finite-element study,





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